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Mc Avoy appeared in the 2009 film The Last Station, based on the 1990 novel by Jay Parini, about the final year of Leo Tolstoy's life; the film co-starred Mc Avoy's wife, Anne-Marie Duff.
Mc Avoy is currently working on Robert Redford's The Conspirator.
His first international starring role was as Leto Atreides II in the 2003 Sci Fi Channel miniseries Frank Herbert's Children of Dune (adapted from Frank Herbert's novels).
In 2006, Mc Avoy starred alongside Forest Whitaker as Dr. The film is an adaptation of Giles Foden's novel of the same name and gives a fictionalized account of the regime of the brutal Ugandan dictator Idi Amin during the 1970s, as seen by his (fictional) personal physician and adviser.
The character of Garrigan is a composite of several men who were close to Amin, most notably Englishman Bob Astles, who was a top adviser to Amin during his regime and became known in Uganda as "The White Rat".
He is also said to be highly considered for the part of Kurt Cobain in the upcoming biopic Heavier than Heaven.
Mc Avoy is a celebrity supporter of the British Red Cross with whom he travelled to Uganda to raise awareness of the projects there.
Mc Avoy was set to star in the upcoming film Live With It, which will be directed by Nicole Holofcener and produced by Seth Rogen, but dropped out and was replaced by Joseph Gordon-Levitt.