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Leonard and Leslie would have a short-lived romantic relationship.
Laurie Metcalf, who portrayed Roseanne's sister Jackie Harris, has appeared as Mary Cooper, mother of Leonard's roommate, Sheldon.
Galecki played a young delinquent in A Family Torn Apart, a 1993 TV movie based on a true story about a serial killer.
The widely popular comedy by Douglas Carter Beane had a successful run at Second Stage and moved to the Cort Theatre.
The play closed on February 18, 2007, with Galecki taking home a 2007 Theater World Award for his performance.
He played Leonard Hofstadter in the CBS sitcom The Big Bang Theory (2007–2019) and David Healy in the ABC sitcom Roseanne (1992–1997; 2018).
Galecki also appeared in the films National Lampoon's Christmas Vacation (1989), Prancer (1989), Suicide Kings (1997), I Know What You Did Last Summer (1997), Bookies (2003), In Time (2011), and Rings (2017).
He would remain in the role of David Healy until the end of Roseanne's run in 1997, with the character eventually marrying Darlene and fathering two children with her.